神经科学
髓鞘
轴突
外周神经系统
神经系统
雪旺细胞
生物
中枢神经系统
神经再生
少突胶质细胞
神经胶质
平衡
细胞生物学
标识
DOI:10.1016/j.conb.2016.03.006
摘要
The remarkable interaction between glial cells and axons is crucial for nervous system development and homeostasis. Alterations in this continuous communication can cause severe pathologies that can compromise the integrity of the nervous system. The most dramatic consequence of this interaction is the generation of the myelin sheath, made by myelinating glial cells: Schwann cells in the peripheral nervous system and oligodendrocytes in the central nervous system. In this review I will focus on signals coming from axons in the first part and then on those from Schwann cells that promote the formation and the maintenance of peripheral myelin. I will discuss their inter-relationship together with seminal and important advances recently made.
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