HPLC enantioseparation on a homochiral MOF–silica composite as a novel chiral stationary phase

Using enantiopure (R)-2,2′-dihydroxy-1,1′-binaphthalene-6,6′-dicarboxylic acid as a starting material, we prepared three homochiral MOFs that were further used as chiral stationary phases for HPLC to separate the enantiomers.