牙周炎
失调
肠道菌群
免疫学
炎症
免疫系统
全身炎症
生物
口腔感染
医学
微生物学
牙科
作者
Yifan Zhao,Yi Liu,Jia Lü
摘要
Abstract Periodontitis is widely acknowledged as the most prevalent type of oral inflammation, arising from the dynamic interplay between oral pathogens and the host's immune responses. It is also recognized as a contributing factor to various systemic diseases. Dysbiosis of the oral microbiota can significantly alter the composition and diversity of the gut microbiota. Researchers have delved into the links between periodontitis and systemic diseases through the “oral–gut” axis. However, whether the associations between periodontitis and the gut microbiota are simply correlative or driven by causative mechanistic interactions remains uncertain. This review investigates how dysbiosis of the gut microbiota impacts periodontitis, drawing on existing preclinical and clinical data. This study highlights potential mechanisms of this interaction, including alterations in subgingival microbiota, oral mucosal barrier function, neutrophil activity, and abnormal T‐cell recycling, and offers new perspectives for managing periodontitis, especially in cases linked to systemic diseases.
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