硫酸软骨素
干细胞
类风湿性关节炎
化学
滑液
自愈水凝胶
免疫学
细胞生物学
医学
病理
糖胺聚糖
生物
骨关节炎
生物化学
替代医学
有机化学
作者
Van Dat Bui,Jueun Jeon,Van Hieu Duong,Sol Shin,Jungmi Lee,Farrokhroo Ghahari,Chan Ho Kim,Young-Sik Jo,Won‐Kyo Jung,Wooram Um,Jae Hyung Park
标识
DOI:10.1016/j.jconrel.2024.08.050
摘要
For the non-invasive treatment of rheumatoid arthritis (RA), a chondroitin sulfate C (CSC)-based dissolving microneedles (cMN) was prepared to deliver human adipose stem cell-derived extracellular vesicles (hASC-EV) into inflamed joints. Owing to their anti-inflammatory function, the hASC-EV-bearing cMN (EV@cMN) significantly suppressed activated fibroblast-like synoviocytes (aFLS) and M1 macrophages (M1), which are responsible for the progression of RA. In addition, EV@cMN facilitated the chondrogenic differentiation of bone marrow-derived stem cells. In mice with collagen-induced arthritis, EV@cMN efficiently delivered both hASC-EV and CSC to inflamed joints. Interestingly, pro-inflammatory cytokines in the inflamed joints were remarkably downregulated by the synergistic effect of CSC and hASC-EV. Consequently, as judged from the overall clinical score and joint swelling, EV@cMN showed an outstanding therapeutic effect, even comparable to the wild-type mice, without significant adverse effects. Overall, EV@cMN might have therapeutic potential for RA by efficiently delivering CSC and hASC-EV into the inflamed joints in a non-invasive manner.
科研通智能强力驱动
Strongly Powered by AbleSci AI