姜黄素
吸附
生物利用度
药物输送
纳米颗粒
化学
控制释放
化学工程
材料科学
核化学
纳米技术
药理学
有机化学
生物化学
医学
工程类
作者
Huỳnh Vủ Thanh Lương,My Tran Diep,Ngoc Yen Nguyen,Duy Toàn Phạm,Ngoc-Hanh Cao-Luu,Taekjip Ha
标识
DOI:10.1016/j.jddst.2024.105465
摘要
The applications of alginate-functionalized magnetite nanoparticles (Fe3O4@Alg NPs) for drug delivery have been limited reported. In this study, Fe3O4@Alg NPs was successfully formulated using the co-precipitation method for the adsorption and delivery of curcumin in both oral and injectable routes. The Fe3O4@Alg NPs were synthesized under optimized conditions with a high saturation magnetization value and negligible remnant magnetization. Curcumin was efficiently integrated into the system through adsorption, achieving a drug encapsulation efficiency of 71% over 12 h, an average NPs size of 100–200 nm, a 1.2-time increase in the curcumin solubility, with insignificant hemolytic effects at concentrations of up to 20 mg mL−1. The adsorption isotherms and kinetic studies showed that the drug adsorption process was rapid, with low slope coefficient, high adsorption capacity of 5.981 mg g−1, and monolayer of curcumin physically adsorbed onto the NPs surfaces. Moreover, the Fe3O4@Alg NPs could protect curcumin from the acidic gastric environment and sustainably release it under simulated physiological (pH 7.4) and intestinal conditions (pH 6.8), with the release percentages of 93.48% and ∼100%, respectively. In summary, this study demonstrated the significant potential of Fe3O4@Alg NPs in enhancing the bioavailability of curcumin. These nanoparticles can be further explored as a promising distribution system for both oral and injectable administration.
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