明胶
伤口愈合
胶粘剂
粘附
自愈水凝胶
体内
极限抗拉强度
材料科学
伤口敷料
生物医学工程
壳聚糖
共价键
化学
复合材料
外科
高分子化学
医学
有机化学
图层(电子)
生物技术
生物
作者
Yu‐Chien Lin,Huey‐Yuan Wang,Yao-Chun Tang,Wan-Rong Lin,Ching‐Li Tseng,Chih-Chien Hu,Ren‐Jei Chung
标识
DOI:10.1016/j.ijbiomac.2023.128845
摘要
Gelatin, widely employed in hydrogel dressings, faces limitations when used in high fluid environments, hindering effective material adhesion to wound sites and subsequently reducing treatment efficacy. The rapid degradation of conventional hydrogels often results in breakdown before complete wound healing. Thus, there is a pressing need for the development of durable adhesive wound dressings. In this study, 3-glycidoxypropyltrimethoxysilane (GPTMS) was utilized as a coupling agent to create gelatin-silica hybrid (G-H) dressings through the sol-gel method. The coupling reaction established covalent bonds between gelatin and silica networks, enhancing structural stability. Dopamine (DP) was introduced to this hybrid (G-H-D) dressing to further boost adhesiveness. The efficacy of the dressings for wound management was assessed through in-vitro and in-vivo tests, along with ex-vivo bioadhesion testing on pig skin. Tensile bioadhesion tests demonstrated that the G-H-D material exhibited approximately 2.5 times greater adhesion to soft tissue in wet conditions compared to pure gelatin. Moreover, in-vitro and in-vivo wound healing experiments revealed a significant increase in wound healing rates. Consequently, this material shows promise as a viable option for use as a moist wound dressing.
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