下调和上调
环氧合酶
光敏剂
癌症研究
药理学
光动力疗法
体内
炎症
化学
医学
免疫学
生物化学
酶
生物
有机化学
基因
生物技术
作者
Wei Zhang,Baixue Yu,Xia‐Yun Chen,Meng‐Yi Yan,Qianqian Liu,Yibin Liu,Yang Ni,Hua Cai,Ni Yan,Renjiang Kong,Hong Cheng,Shiying Li,Ali Chen
出处
期刊:Small
[Wiley]
日期:2024-02-11
被引量:1
标识
DOI:10.1002/smll.202309882
摘要
Abstract Negative therapeutic feedback of inflammation would extensively attenuate the antitumor effect of photodynamic therapy (PDT). In this work, tumor homing chimeric peptide rhomboids (designated as NP‐Mel) are fabricated to improve photodynamic performance by inhibiting PDT‐upregulated cyclooxygenase‐2 (COX‐2). The hydrophobic photosensitizer of protoporphyrin IX (PpIX) and palmitic acid are conjugated onto the neuropilin receptors (NRPs) targeting peptide motif (CGNKRTR) to obtain tumor homing chimeric peptide (Palmitic‐K(PpIX)CGNKRTR), which can encapsulate the COX‐2 inhibitor of meloxicam. The well dispersed NP‐Mel not only improves the drug stability and reactive oxygen species (ROS) production ability, but also increase the breast cancer targeted drug delivery to intensify the PDT effect. In vitro and in vivo studies verify that NP‐Mel will decrease the secretion of prostaglandin E2 (PGE2) after PDT treatment, inducing the downregulation of IL‐6 and TNF‐α expressions to suppress PDT induced inflammation. Ultimately, an improved PDT performance of NP‐Mel is achieved without inducing obvious systemic toxicity, which might inspire the development of sophisticated nanomedicine in consideration of the feedback induced therapeutic resistance.
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