恐惧条件反射
光遗传学
扁桃形结构
消光(光学矿物学)
神经科学
大脑中的恐惧处理
心理学
海马体
英语
基底外侧杏仁核
齿状回
记忆巩固
生物
古生物学
作者
Yosif Zaki,William Mau,Christine Cincotta,Amy Monasterio,Emma Odom,Emily Doucette,Stephanie L. Grella,Emily Merfeld,Monika Shpokayte,Steve Ramirez
标识
DOI:10.1038/s41386-022-01407-0
摘要
The formation and extinction of fear memories represent two forms of learning that each engage the hippocampus and amygdala. How cell populations in these areas contribute to fear relapse, however, remains unclear. Here, we demonstrate that, in male mice, cells active during fear conditioning in the dentate gyrus of hippocampus exhibit decreased activity during extinction and are re-engaged after contextual fear relapse. In vivo calcium imaging reveals that relapse drives population dynamics in the basolateral amygdala to revert to a network state similar to the state present during fear conditioning. Finally, we find that optogenetic inactivation of neuronal ensembles active during fear conditioning in either the hippocampus or amygdala is sufficient to disrupt fear expression after relapse, while optogenetic stimulation of these same ensembles after extinction is insufficient to artificially mimic fear relapse. These results suggest that fear relapse triggers a partial re-emergence of the original fear memory representation, providing new insight into the neural substrates of fear relapse.
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