纳米载体
倍半硅氧烷
柠檬酸
材料科学
纳米颗粒
盐酸阿霉素
药物输送
磁性纳米粒子
化学工程
核化学
纳米技术
聚合物
有机化学
化学
阿霉素
医学
外科
工程类
化疗
复合材料
作者
Jafar Rezaie,Nasrollah Jabbari,Sina Sharifi,Ali Akbari
标识
DOI:10.1016/j.matlet.2022.133516
摘要
In this work, magnetic nanoparticles coated with citric acid (Fe3O4@Cit) were synthesized via co-precipitation strategy. Then, Fe3O4@Cit was modified with octa-aminopropyl polyhedral oligomeric silsesquioxane hydrochloride salt nanoparticles (OAPOSS NPs) by amidation reaction between carboxylic acid end groups on Fe3O4@Cit and the amine groups of OAPOSS surface (Fe3O4@Cit@OAPOSS). The key point of this approach is utilizing a symmetric nanosized cagelike POSS NPs as coating material to obtain novel hybrid drug nanocarrier. The successful preparation of nanocarrier (Fe3O4@Cit@OAPOSS) was confirmed by various techniques. Drug loading and release behaviors of Fe3O4@Cit@OAPOSS were evaluated using doxorubicin (DOX), a standard anticancer model drug, in neutral and acidic conditions. Moreover, Higuchi and Korsmeyer-Peppas models were used to study the release kinetics of DOX. Obtained results confirmed the suitability of Fe3O4@Cit@OAPOSS as a potential novel nanocarrier for drug delivery.
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