医学
单克隆抗体
阿尔茨海默病
淀粉样蛋白(真菌学)
疾病
抗体
单克隆
免疫学
病理
作者
Christopher H. van Dyck,Chad J. Swanson,Paul M. Thompson,Randall J. Bateman,Christopher Chen,Michelle Gee,Michio Kanekiyo,David Li,Larisa Reyderman,Sharon Cohen,Lutz Frölich,Sadao Katayama,Marwan Sabbagh,Bruno Vellas,David Watson,Shobha Dhadda,Michael C. Irizarry,Lynn D. Kramer,Takeshi Iwatsubo
标识
DOI:10.1056/nejmoa2212948
摘要
The accumulation of soluble and insoluble aggregated amyloid-beta (Aβ) may initiate or potentiate pathologic processes in Alzheimer’s disease. Lecanemab, a humanized IgG1 monoclonal antibody that binds with high affinity to Aβ soluble protofibrils, is being tested in persons with early Alzheimer’s disease.
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