Effects of native and modified low-density lipoproteins on mitophagy

Recently, Liu and colleagues reported the mechanism of endothelial mitophagy inhibition by low shear stress [ [1] Liu W. Song H. Xu J. Guo Y. Zhang C. Yao Y. Zhang H. Liu Z. Li Y.-C. Low shear stress inhibits endothelial mitophagy via caveolin-1/miR-7-5p/SQSTM1 signaling pathway. Atherosclerosis. 2022; 356: 9-17https://doi.org/10.1016/j.atherosclerosis.2022.07.014 Abstract Full Text Full Text PDF PubMed Scopus (9) Google Scholar ]. This finding is important for understanding the role of mitophagy in atherogenesis. We would like to supplement this thought with our own results. We shall provide evidence below that naturally occurring multiply modified low-density lipoprotein (mmLDL) isolated from the blood of atherosclerotic patients and native LDL have different effects on mitophagy. Low shear stress inhibits endothelial mitophagy via caveolin-1/miR-7-5p/SQSTM1 signaling pathwayAtherosclerosisVol. 356PreviewMitophagy plays a crucial role in mitochondrial homeostasis and is closely associated with endothelial function. However, the mechanism underlying low blood flow shear stress (SS), detrimental cellular stress, regulating endothelial mitophagy is unclear. This study aimed to investigate whether low SS inhibits endothelial mitophagy via caveolin-1 (Cav-1)/miR-7-5p/Sequestosome 1 (SQSTM1) signaling pathway. Full-Text PDF