皮质酮
药理学
体内
神经保护
乳酸脱氢酶
抗抑郁药
行为绝望测验
细胞凋亡
神经炎症
化学
单胺类神经递质
医学
内分泌学
受体
内科学
生物
生物化学
血清素
炎症
海马体
酶
激素
生物技术
作者
Ziwei Ma,Yuming Yu,Mingxing Gao,Peng Chen,Huixia Hong,Dingle Yu,Zhenjiang Liang,Yu Bai,Qinlian Ye,Yachao Wang,Guodong Huang,Hui Tan
标识
DOI:10.1021/acschemneuro.4c00081
摘要
Depression is a common mental disorder. In recent years, more and more attention has been paid to depression and its etiology and pathogenesis. This review aims to explore the neuroprotective and antidepressant effects of hop components. By establishing an in vitro cell damage model using PC12 cells induced by corticosterone (CORT) and an in vivo depression model through the intracranial injection of lipopolysaccharide (LPS) in mice, hop ethyl acetate extract (HEA) was used to study the protective effect and mechanism of HEA on neuronal cells in vitro and the antidepression effect and mechanism in vivo. The results showed that HEA increased the survival and decreased the rate of lactate dehydrogenase (LDH) release, apoptosis, and the ROS and NO content of CORT-induced PC12 cells. HEA alleviated depressive-like behavior, neuroinflammation, reduction of norepinephrine, and dendritic spines induced by intracerebroventricular injection of LPS in mice and increases the expression levels of BDNF, SNAP 25, and TrkB proteins without any significant side effects or toxicity. Hops demonstrated significant comprehensive utilization value, and this work provided an experimental basis for the role of hops in the treatment of depression and provided a basis for the development of HEA for antidepressant drugs or dietary therapy products.
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