Prevalence and outcomes of polycystic kidney disease in African populations: A systematic review

医学 多囊肾病 包装D1 疾病 肾脏疾病 肾功能 内科学 常染色体显性多囊肾病 人口 入射(几何) 透析 肾病 儿科 糖尿病 内分泌学 环境卫生 光学 物理
作者
Modou Ndongo,Lot Motoula Nehemie,Baratou Coundoul,Abou Abdallah Malick Diouara,Sidy Mohamed Seck
出处
期刊:World journal of nephrology [Baishideng Publishing Group Co (World Journal of Nephrology)]
卷期号:13 (1) 被引量:1
标识
DOI:10.5527/wjn.v13.i1.90402
摘要

BACKGROUND Polycystic kidney disease (PKD) is the most common genetic cause of kidney disease. It is a progressive and irreversible condition that can lead to end-stage renal disease and many other visceral complications. Current comprehensive data on PKD patterns in Africa is lacking. AIM To describe the prevalence and outcomes of PKD in the African population. METHODS A literature search of PubMed, African journal online, and Google Scholar databases between 2000 and 2023 was performed. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses were followed to design the study. Clinical presentations and outcomes of patients were extracted from the included studies. RESULTS Out of 106 articles, we included 13 studies from 7 African countries. Ten of them were retrospective descriptive studies concerning 943 PKD patients with a mean age of 47.9 years. The accurate prevalence and incidence of PKD were not known but it represented the third causal nephropathy among dialysis patients. In majority of patients, the diagnosis of the disease was often delayed. Kidney function impairment, abdominal mass, and hypertension were the leading symptoms at presentation with a pooled prevalence of 72.1% (69.1–75.1), 65.8% (62.2–69.4), and 57.4% (54.2–60.6) respectively. Hematuria and infections were the most frequent complications. Genotyping was performed in few studies that revealed a high proportion of new mutations mainly in the PKD1 gene. CONCLUSION The prevalence of PKD in African populations is not clearly defined. Clinical symptoms were almost present with most patients who had kidney function impairment and abdominal mass at the diagnostic. Larger studies including genetic testing are needed to determine the burden of PKD in African populations.

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