河豚毒素
生化工程
纳米技术
高分辨率
样品制备
复矩阵
计算机科学
色谱法
计算生物学
生物技术
化学
数据科学
生物
材料科学
工程类
地理
遥感
生物物理学
作者
Cong Hu,Yuan Zhang,Yu Zhou,Yangjiayi Xiang,Zhifei Liu,Zhihong Wang,Xuesong Feng
标识
DOI:10.1021/acs.jafc.2c04106
摘要
Tetrodotoxin (TTX), found in various organisms including pufferfish, is an extremely potent marine toxin responsible for numerous food poisoning accidents. Due to its serious toxicity and public health threat, detecting TTX and its analogues in diverse food matrices with a simple, fast, efficient method has become a worldwide concern. This review summarizes the advances in sample preparation and analytical methods for the determination of TTX and its analogues, focusing on the latest development over the past five years. Current state-of-the-art technologies, such as solid-phase microextraction, online technology, novel injection technology, two-dimensional liquid chromatography, high-resolution mass spectrometry, newly developed lateral flow immunochromatographic strips, immunosensors, dual-mode aptasensors, and nanomaterials-based approaches, are thoroughly discussed. The advantages and limitations of different techniques, critical comments, and future perspectives are also proposed. This review is expected to provide rewarding insights to the future development and broad application of pretreatment and detection methods for TTX and its analogues.
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