自愈水凝胶
生物相容性
伤口愈合
单宁酸
复合数
细胞外基质
粘膜下层
化学
医学
材料科学
复合材料
免疫学
高分子化学
生物化学
外科
有机化学
冶金
作者
Qingyi Zhang,Jie Tan,Rong Nie,Yuting Song,Xingli Zhou,Zi-Yuan Feng,Kai Huang,Chen‐Yu Zou,Hengjie Zhang,Longmei Zhao,Xiuzhen Zhang,Yanlin Jiang,Limin Liu,Jesse Li‐Ling,Huiqi Xie
标识
DOI:10.1016/j.compositesb.2023.110550
摘要
Small intestinal submucosa (SIS) hydrogel is a potential candidate for wound dressing since its excellent biocompatibility and bioactivities. However, the intrinsic lack of sufficient immunomodulatory activities has limited its application. Herein, tannic acid (TA) and interleukin-10 (IL-10) were supplemented to the SIS hydrogel to fabricate a novel composite hydrogel to confer an immunomodulatory activity. In addition to the improvement in swelling and anti-degradation properties, the composite SIS hydrogel has attained satisfying free radical scavenging and sustained IL-10 release. Meanwhile, the hydrogel possessed excellent anti-oxidative and immunomodulatory abilities to promote the polarization of M2c macrophages, thereby regulating collagen synthesis and providing a favorable immune environment for angiogenesis and extracellular matrix remodeling. Above results have therefore provided a facile but effective strategy to improve the therapeutic effects of the SIS hydrogel and expand its scope of clinical applications.
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