核糖核酸
Tau病理学
RNA结合蛋白
τ蛋白
细胞器
生物
细胞生物学
功能(生物学)
神经科学
疾病
化学
计算生物学
阿尔茨海默病
遗传学
医学
基因
病理
作者
Evan Lester,Roy Parker
标识
DOI:10.1177/10738584231154551
摘要
The tau protein is a key contributor to multiple neurodegenerative diseases. The pathology of tau is thought to be related to tau’s propensity to form self-templating fibrillar structures that allow tau fibers to propagate in the brain by prion-like mechanisms. Unresolved issues with respect to tau pathology are how the normal function of tau and its misregulation contribute to disease, how cofactors and cellular organelles influence the initiation and propagation of tau fibers, and determining the mechanism of tau toxicity. Herein, we review the connection between tau and degenerative diseases, the basis for tau fibrilization, and how that process interacts with cellular molecules and organelles. One emerging theme is that tau interacts with RNA and RNA-binding proteins, normally and in pathologic aggregates, which may provide insight into alterations in RNA regulation observed in disease.
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