爱泼斯坦-巴尔病毒
病毒
癌变
生物
病毒学
发病机制
免疫学
恶性转化
无症状的
癌症研究
医学
癌症
遗传学
病理
作者
Yu Hui,Erle S. Robertson
出处
期刊:Viruses
[MDPI AG]
日期:2023-03-09
卷期号:15 (3): 714-714
被引量:27
摘要
Epstein–Barr virus (EBV) is the first identified human oncogenic virus that can establish asymptomatic life-long persistence. It is associated with a large spectrum of diseases, including benign diseases, a number of lymphoid malignancies, and epithelial cancers. EBV can also transform quiescent B lymphocytes into lymphoblastoid cell lines (LCLs) in vitro. Although EBV molecular biology and EBV-related diseases have been continuously investigated for nearly 60 years, the mechanism of viral-mediated transformation, as well as the precise role of EBV in promoting these diseases, remain a major challenge yet to be completely explored. This review will highlight the history of EBV and current advances in EBV-associated diseases, focusing on how this virus provides a paradigm for exploiting the many insights identified through interplay between EBV and its host during oncogenesis, and other related non-malignant disorders.
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