Incidence of antibody–drug conjugates-related pneumonitis in patients with solid tumors: A systematic review and meta-analysis

医学 入射(几何) 肺炎 内科学 置信区间 荟萃分析 胃肠病学 光学 物理
作者
Zijun Zhu,Guoshuang Shen,Jinming Li,Tian Qiu,Qianqian Fang,Yong-Hui Zheng,Yuanfang Xin,Zhilin Liu,Fuxing Zhao,Dengfeng Ren,Jiuda Zhao
出处
期刊:Critical Reviews in Oncology Hematology [Elsevier]
卷期号:184: 103960-103960 被引量:9
标识
DOI:10.1016/j.critrevonc.2023.103960
摘要

Antibody-drug conjugates (ADCs) have demonstrated significant efficacy in treating solid tumors. However, the occurrence of ADC drug-associated pneumonitis can limit the use of ADCs or have severe consequences, and we know comparatively little about this.PubMed, EMBASE, and the Cochrane library were exhaustively searched for articles and conference abstracts published before September 30, 2022. Two authors independently extracted data from the included studies. A random-effects model was used to conduct a meta-analysis of the relevant outcomes. Forest plots reflected the incidence rates from each study, and binomial methods were used to calculate the 95 % confidence interval.This meta-analysis included 7732 patients from 39 studies and evaluated the incidence of ADCs drug-associated pneumonitis which have received market approval for the treatment of solid tumors. The total incidence of solid tumors for all-grade pneumonitis was 5.86 % (95 % CI, 3.54-8.66 %) and for grade ≥3 was 0.68 % (95 % CI, 0.18-1.38 %). The incidence of all-grade pneumonitis was 5.08 % (95 % CI, 2.76-7.96 %) and for grade ≥3 was 0.57 % (95 % CI, 0.10-1.29 %) with ADC monotherapy. The incidence of all-grade and grade ≥3 pneumonitis in trastuzumab deruxtecan (T-DXd) was 13.58 % (95 % CI, 9.43-18.29 %) and 2.19 % (95 % CI, 0.94-3.81 %), respectively, the highest in ADC therapy. Total incidence of all-grade pneumonitis was 10.58 % (95 % CI, 4.34-18.81 %) and for grade ≥3 pneumonitis was 1.29 % (95 % CI, 0.22-2.92 %) with ADC combination therapy. The incidence of pneumonitis was higher with combination therapy than with monotherapy in both all-grade and grade ≥3 groups, but there was no statistical significance (P = .138 and P = .281, respectively). The incidence of ADC-associated pneumonitis in non-small cell lung cancer (NSCLC) was 22.18 % (95 % CI, 2.14-52.61 %), the highest among solid tumors. The 11 included studies reported 21 pneumonitis-related deaths.Our findings will assist clinicians in choosing the optimal therapeutic options for patients with solid tumors treated with ADCs.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
调研昵称发布了新的文献求助10
1秒前
小马甲应助hellojwx采纳,获得10
2秒前
2秒前
peach发布了新的文献求助10
2秒前
统领七届完成签到,获得积分10
3秒前
3秒前
3秒前
冰coke完成签到,获得积分10
4秒前
4秒前
李小刀完成签到,获得积分10
6秒前
共享精神应助时尚雨兰采纳,获得10
6秒前
科研小白发布了新的文献求助10
6秒前
卷心菜发布了新的文献求助10
6秒前
莫莫发布了新的文献求助10
7秒前
8秒前
Daisy666完成签到 ,获得积分10
8秒前
8秒前
9秒前
爱静静应助陈王采纳,获得10
9秒前
听蝉完成签到,获得积分10
10秒前
10秒前
专注绿真完成签到,获得积分10
11秒前
11秒前
天天快乐应助大仙采纳,获得10
11秒前
11秒前
13秒前
薰硝壤应助无风采纳,获得20
13秒前
奕初阳发布了新的文献求助10
13秒前
一只橙子完成签到,获得积分10
15秒前
兴奋芷发布了新的文献求助10
15秒前
15秒前
TY发布了新的文献求助10
16秒前
科研通AI2S应助2123121321321采纳,获得10
16秒前
16秒前
douny完成签到,获得积分10
16秒前
大大怪z发布了新的文献求助10
16秒前
jiaying_Z完成签到,获得积分10
17秒前
hy完成签到 ,获得积分10
17秒前
18秒前
哈哈哈完成签到,获得积分10
18秒前
高分求助中
Evolution 10000
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
юрские динозавры восточного забайкалья 800
English Wealden Fossils 700
Foreign Policy of the French Second Empire: A Bibliography 500
Chen Hansheng: China’s Last Romantic Revolutionary 500
China's Relations With Japan 1945-83: The Role of Liao Chengzhi 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3147582
求助须知:如何正确求助?哪些是违规求助? 2798713
关于积分的说明 7830993
捐赠科研通 2455488
什么是DOI,文献DOI怎么找? 1306841
科研通“疑难数据库(出版商)”最低求助积分说明 627934
版权声明 601587