ABSTRACT The U.S. National Health and Nutrition Examination Survey (NHANES) physical activity monitor datasets for 2011–12 and 2013–14 were released in late 2020. To date, there has been limited interpretation of these nationally representative wrist‐worn accelerometer data (summarized and reported in Monitor Independent Movement Summary [MIMS] units) and their relationships with health‐related outcomes. This study examined the associations between free‐living Daily MIMS (volume), Peak 1 MIMS and Peak 30 MIMS (intensity), and risk of Metabolic Syndrome (MetS). Data from adults ( N =3787; 18–80+ years) in the 2011–12 and 2013–14 NHANES cycles with health examination and accelerometry data were included. Accelerometer data were processed into Peak 1 MIMS and Peak 30 MIMS (MIMS/min), and Daily MIMS (MIMS/day). Design‐based generalized linear and logistic regressions, and a sample‐weighted decision tree, were used to examine associations between MIMS variables and MetS risk factors. Lower Peak 1 MIMS , Peak 30 MIMS, and Daily MIMS were observed for every one‐unit increase in the number of risk factors −3.9 [95% CI: −4.3, −3.4] and −2.3 [−2.6, −2.1] MIMS/min, (−672.1 [−772.7, −571.5] MIMS/day, respectively, all p < 0.001). The Decision Tree classified individuals ≥ 46.5 years with a Daily MIMS ≥ 12 245 MIMS/day and a Peak 30 MIMS < 45.1 MIMS/min as having MetS (≥ 3 risk factors). Individuals < 46.5 years with a Peak 1 MIMS ≥ 62.9 MIMS/min were classified with 0 risk factors. Higher Daily MIMS and Peak MIMS were associated with an absence of MetS risk factors, with a progressive decline as the number of risk factors increased. These findings may be considered as preliminary benchmarks for Daily MIMS and Peak MIMS associated with cardiometabolic risk.