Chemiluminescent Fe3O4@Nickel–Cobalt Double Hydroxide Magnetic Core–Shell Nanomaterial as an Analytical Interface for Label-Free CYFRA21-1 Immunosensing

Cytokeratin 19 fragment (CYFRA21-1) is considered to be a potential marker for the diagnosis and of classification of lung cancer. It is highly desired to develop rapid and highly sensitive label-free chemiluminescence (CL) immunosensors for the detection of CYFRA21-1. In this work, magnetic core-shell nanocomposite Fe