A Transfer Learning Radiomics Nomogram to Predict the Postoperative Recurrence of Advanced Gastric Cancer

ABSTRACT Background and Aim In this study, a transfer learning (TL) algorithm was used to predict postoperative recurrence of advanced gastric cancer (AGC) and to evaluate its value in a small‐sample clinical study. Methods A total of 431 cases of AGC from three centers were included in this retrospective study. First, TL signatures (TLSs) were constructed based on different source domains, including whole slide images (TLS‐WSIs) and natural images (TLS‐ImageNet). Clinical model and non‐TLS based on CT images were constructed simultaneously. Second, TL radiomic model (TLRM) was constructed by combining optimal TLS and clinical factors. Finally, the performance of the models was evaluated by ROC analysis. The clinical utility of the models was assessed using integrated discriminant improvement (IDI) and decision curve analysis (DCA). Results TLS‐WSI significantly outperformed TLS‐ImageNet, non‐TLS, and clinical models ( p < 0.05). The AUC value of TLS‐WSI in training cohort was 0.9459 (95CI%: 0.9054, 0.9863) and ranged from 0.8050 (95CI%: 0.7130, 0.8969) to 0.8984 (95CI%: 0.8420, 0.9547) in validation cohorts. TLS‐WSI and the nodular or irregular outer layer of gastric wall were screened to construct TLRM. The AUC value of TLRM in training cohort was 0.9643 (95CI%: 0.9349, 0.9936) and ranged from 0.8561 (95CI%: 0.7571, 0.9552) to 0.9195 (95CI%: 0.8670, 0.9721) in validation cohorts. The IDI and DCA showed that the performance of TLRM outperformed the other models. Conclusion TLS‐WSI can be used to predict postoperative recurrence in AGC, whereas TLRM is more effective. TL can effectively improve the performance of clinical research models with a small sample size.