微卫星不稳定性
林奇综合征
医学
结直肠癌
内科学
肿瘤科
DNA错配修复
免疫疗法
回顾性队列研究
癌症
总体生存率
单变量分析
多元分析
微卫星
遗传学
基因
生物
等位基因
作者
Cody Eslinger,Daniel Walden,Alyssa McGary,Oluwadunni Emiloju,Daniel H. Ahn,Mohamad Bassam Sonbol,Tanios Bekaii‐Saab,Mojun Zhu,Joleen M. Hubbard,Christina Wu
出处
期刊:Cancer
[Wiley]
日期:2025-02-11
卷期号:131 (4)
摘要
In a retrospective study of patients with Lynch syndrome vs non‐Lynch syndrome and microsatellite instability high colorectal cancer, there were no observed differences with immune checkpoint inhibitors toward progression‐free survival or overall survival. Univariate analysis of Stage IV patients showed BRAF V600E mutations were associated with decreased survival.
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