LncRNA TINCR: an irreplaceable biological target in human malignancies

Abstract: Currently, malignant tumors increasingly affect young people, which has caused a catastrophic financial burden on people worldwide. lncRNA has gained considerable attention because of its importance in the early diagnosis and treatment of tumors. In addition, since terminal differentiation-induced ncRNA (abbreviated as TINCR) was reported in a Nature article, it has received focus on targeted therapy of tumors, especially in digestive system malignant tumors. This review aims to reveal and summarize its important molecular mechanisms in human malignancies. In this review, relevant research works involving the relationship between TINCR and human malignancies are gathered through systematic retrieval of PubMed. TINCR is expressed bidirectionally in human malignancies. TINCR functions primarily as a ceRNA in human malignancies, and it also functions at the transcriptional level. Moreover, lncRNA TINCR has the potential to become a novel biomolecular marker of human malignancies.