纳米凝胶
材料科学
葡萄膜炎
氧化铈
视网膜
氧化物
铈
纳米技术
免疫学
医学
眼科
冶金
药物输送
作者
Y. Jin,Dawen Cai,Li‐Hua Mo,Guanghui Jing,Li Zeng,Hui‐Ming Cheng,Qi Guo,Mali Dai,Yuqin Wang,Jinrun Chen,Guojun Chen,Xingyi Li,Shuai Shi
出处
期刊:Biomaterials
[Elsevier]
日期:2024-09-01
卷期号:309: 122617-122617
被引量:2
标识
DOI:10.1016/j.biomaterials.2024.122617
摘要
Effectively addressing retinal issues represents a pivotal aspect of blindness-related diseases. Novel approaches involving reducing inflammation and rebalancing the immune response are paramount in the treatment of these conditions. This study delves into the potential of a nanogel system comprising polyethylenimine-benzene boric acid-hyaluronic acid (PEI-PBA-HA). We have evaluated the collaborative impact of cerium oxide nanozyme and chemokine CX3CL1 protein for targeted immunomodulation and retinal protection in uveitis models. Our nanogel system specifically targets the posterior segment of the eyes. The synergistic effect in this area reduces oxidative stress and hampers the activation of microglia, thereby alleviating the pathological immune microenvironment. This multifaceted drug delivery system disrupts the cycle of oxidative stress, inflammation, and immune response, suppressing initial immune cells and limiting local retinal structural damage induced by excessive immune reactions. Our research sheds light on interactions within retinal target cells, providing a promising avenue for the development of efficient and innovative drug delivery platforms.
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