孟德尔随机化
医学
危险系数
全国健康与营养检查调查
置信区间
四分位数
内科学
单核苷酸多态性
冲程(发动机)
比例危险模型
遗传学
人口
遗传变异
基因
基因型
环境卫生
机械工程
工程类
生物
作者
Yongan Jiang,Jing Shen,Peng Chen,JiaHong Cai,Yangyang Zhao,Jiawei Liang,Cai Jian-hui,ShiQi Cheng,Yan Zhang
标识
DOI:10.1097/js9.0000000000001795
摘要
Introduction: The triglyceride glucose index (TyG) is associated with cardiovascular diseases; however, its association with stroke remains unclear. This study aimed to elucidate this relationship by examining two extensive cohort studies using two-sample Mendelian randomization (MR). Methods: Using data from the 1999-2018 National Health and Nutrition Examination Survey (NHANES) and the Medical Information Mart for Intensive Care (MIMIC)-IV, the correlation between TyG (continuous and quartile) and stroke was examined using multivariate Cox regression models and sensitivity analyses. Two-sample MR was employed to establish causality between TyG and stroke using the inverse variance weighting method. Genome-wide association study catalog queries were performed for single nucleotide polymorphism-mapped genes, and the STRING platform used to assess protein interactions. Functional annotation and enrichment analyses were also conducted. Results: From the NHANES and MIMIC-IV cohorts, we included 740 and 589 participants with stroke, respectively. After adjusting for covariates, TyG was linearly associated with the risk of stroke death (NHANES: hazard ratio [HR] 0.64, 95% confidence interval [CI]: 0.41-0.99, P =0.047; Q3 vs. Q1, HR 0.62, 95%CI: 0.40-0.96, P =0.033; MIMIC-IV: HR 0.46, 95%CI: 0.27-0.80, P =0.006; Q3 vs. Q1, HR 0.32, 95%CI: 0.12-0.86; Q4 vs. Q1, HR 0.30, 95%CI: 0.10-0.89, P =0.030, P for trend=0.017). Two-sample MR analysis showed genetic prediction supported a causal association between a higher TyG and a reduced risk of stroke (odds ratio 0.711, 95%CI: 0.641-0.788, P =7.64e -11 ). Conclusions: TyG was causally associated with a reduced risk of stroke. TyG is a critical factor for stroke risk management.
科研通智能强力驱动
Strongly Powered by AbleSci AI