血管生成
光热治疗
材料科学
伤口愈合
抗菌剂
纳米技术
癌症研究
微生物学
医学
免疫学
生物
作者
Ye Guo,Chuankai Zhang,Bingqing Xie,Wei Xu,Zihan Rao,Peirong Zhou,Xuemin Ma,Junliang Chen,Rui Cai,G. Tao,Yun He
标识
DOI:10.1021/acsami.4c07091
摘要
In diabetic patients with skin injuries, bacterial proliferation, accumulation of reactive oxygen species (ROS) in the tissues, and impaired angiogenesis make wound healing difficult. Therefore, eliminating bacteria, removing ROS, and promoting angiogenesis are necessary for treating acute diabetic wounds. In this study, benefiting from the ability of polyphenols to form a metal-phenolic network (MPN) with metal ions, TA-Eu MPN nanoparticles (TM NPs) were synthesized. The prepared photothermal agent CuS NPs and TM NPs were then loaded onto the supporting base and needle tips of PVA/HA (PH) microneedles, respectively, to obtain PH/CuS/TM microneedles. Antibacterial experiments showed that microneedles loaded with CuS NPs could remove bacteria by the photothermal effect.
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