Intravitreal Injection of Anti-Vascular Endothelial Growth Factors Combined with Corticosteroids for the Treatment of Macular Edema Secondary to Retinal Vein Occlusion: A Systematic Review and Meta-Analysis

医学 视网膜中央静脉阻塞 黄斑水肿 视网膜分支静脉阻塞 眼科 曲安奈德 视力 视网膜静脉 科克伦图书馆 阿柏西普 子群分析 荟萃分析 闭塞 外科 贝伐单抗 内科学 化疗
作者
Ehsan Namvar,Masoud Yasemi,M. Hossein Nowroozzadeh,Hamid Ahmadieh
出处
期刊:Seminars in Ophthalmology [Taylor & Francis]
卷期号:39 (1): 109-119 被引量:4
标识
DOI:10.1080/08820538.2023.2249527
摘要

ABSTRACTPurpose To evaluate the efficacy and safety of intravitreal anti-vascular endothelial growth factor (anti-VEGF) and corticosteroid combination therapy for the management of treatment-naïve or recurrent/refractory macular edema caused by retinal vein occlusion (RVO) in comparison with anti-VEGF monotherapy.Methods In this systematic review and meta-analysis study, the data from publications in the electronic databases including PubMed, Embase, Cochrane Library Central Register of Controlled Trials, ISI and Scopus from January 1, 2007, through November 20, 2020, were compiled. Heterogeneity was statistically quantified by the I2 statistic, and meta-analysis was performed using a random-effects model.Results Twenty-four related studies were identified, including a total of 1280 eyes, which consisted of 685 and 507 patients with central retinal vein occlusion (CRVO) and branch retinal vein occlusion (BRVO), respectively. This study demonstrated a greater improvement in best-corrected visual acuity (BCVA) in the combination group compared to anti-VEGF monotherapy for both CRVO and BRVO cases at 6 months after initiating therapy. The improvement in vision was more notable in BRVO cases than in CRVO cases. However, the changes in central macular thickness (CMT) did not differ significantly between the different treatment approaches, and the results were inconclusive. Including all cases with RVO, there was no inferiority in terms of BCVA improvement and CMT reduction in the triamcinolone subgroup compared with the slow-release dexamethasone implant subgroup. A greater improvement was noticed in terms of BCVA in the sequentially treated subgroup compared to the simultaneous treatment subgroup, while there was a greater reduction in CMT in the simultaneous subgroup with the highest reduction recorded at 1 month after treatment.Conclusions This study suggests that combination therapy with intravitreal anti-VEGF and corticosteroid (such as intravitreal or subtenon triamcinolone or dexamethasone implant) has a slightly better effect on improving BCVA in cases with BRVO or CRVO at 6 months compared to monotherapy.KEYWORDS: Combination therapymacular edemameta-analysismonotherapyretinal vein occlusion Disclosure statementNo potential conflict of interest was reported by the author(s).Availability of data and materialsAll data generated or analysed during this study are included in this published article [and its supplementary information files].Author contributionsConception and design: Ehsan Namvar, M. Hossein Nowroozzadeh; the literature searches: Ehsan Namvar, Masoud Yasemi; data analysis: Ehsan Namvar, M. Hossein Nowroozzadeh, Hamid Ahmadieh; drafting: all authors; critical revising: all authors. Final approval: all authors.Supplemental dataSupplemental data for this article can be accessed online at https://doi.org/10.1080/08820538.2023.2249527Additional informationFundingThis study was supported by Shiraz University of Medical Science (Grant# 23121).
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Liury完成签到 ,获得积分10
1秒前
ran123456发布了新的文献求助10
1秒前
上官若男应助柚子采纳,获得10
1秒前
婷婷子发布了新的文献求助20
1秒前
大方的笑萍完成签到 ,获得积分10
1秒前
六六三十六完成签到,获得积分10
2秒前
传奇3应助尔尔采纳,获得30
2秒前
汤飞柏发布了新的文献求助10
2秒前
星河圈揽完成签到,获得积分10
3秒前
story发布了新的文献求助10
3秒前
eden发布了新的文献求助10
3秒前
4秒前
4秒前
5秒前
5秒前
6秒前
znn发布了新的文献求助10
7秒前
无奈行恶应助唱歌不着调采纳,获得10
7秒前
Lily完成签到,获得积分10
8秒前
清脆万声完成签到,获得积分20
8秒前
共享精神应助多金采纳,获得10
8秒前
Owen应助老迟到的沛萍采纳,获得10
9秒前
在水一方应助火火采纳,获得10
10秒前
kk发布了新的文献求助10
10秒前
小羽完成签到,获得积分10
10秒前
10秒前
10秒前
11秒前
mzh发布了新的文献求助10
11秒前
zhang_rx完成签到,获得积分20
11秒前
11秒前
MXG完成签到,获得积分10
12秒前
12秒前
淡淡诗柳发布了新的文献求助10
12秒前
小马甲应助论太刀虾采纳,获得10
12秒前
酷波er应助Xenia采纳,获得10
13秒前
LioXH发布了新的文献求助10
13秒前
lxp完成签到,获得积分10
14秒前
果泥关注了科研通微信公众号
15秒前
15秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3974779
求助须知:如何正确求助?哪些是违规求助? 3519193
关于积分的说明 11197417
捐赠科研通 3255311
什么是DOI,文献DOI怎么找? 1797760
邀请新用户注册赠送积分活动 877150
科研通“疑难数据库(出版商)”最低求助积分说明 806187