Prevalence and risk factors for impaired renal function among Asian patients with nonalcoholic fatty liver disease

医学 非酒精性脂肪肝 内科学 肾功能 肾脏疾病 胃肠病学 肝硬化 瞬态弹性成像 代谢综合征 脂肪肝 糖尿病前期 空腹血糖受损 糖耐量受损 糖尿病 2型糖尿病 内分泌学 疾病 胰岛素抵抗 肥胖 肝纤维化
作者
Chao Sun,George Boon‐Bee Goh,Wan‐Cheng Chow,Wah‐Kheong Chan,Grace Lai‐Hung Wong,Wai‐Kay Seto,Yi‐Hsiang Huang,Han‐Chieh Lin,I‐Cheng Lee,Hye Won Lee,Seung Up Kim,Vincent Wai‐Sun Wong,Jian‐Gao Fan
出处
期刊:Hepatobiliary & Pancreatic Diseases International [Elsevier BV]
卷期号:23 (3): 241-248 被引量:2
标识
DOI:10.1016/j.hbpd.2023.08.004
摘要

Nonalcoholic fatty liver disease (NAFLD) is associated with impaired renal function, and both diseases often occur alongside other metabolic disorders. However, the prevalence and risk factors for impaired renal function in patients with NAFLD remain unclear. The objective of this study was to identify the prevalence and risk factors for renal impairment in NAFLD patients. All adults aged 18–70 years with ultrasound-diagnosed NAFLD and transient elastography examination from eight Asian centers were enrolled in this prospective study. Liver fibrosis and cirrhosis were assessed by FibroScan-aspartate aminotransferase (FAST), Agile 3+ and Agile 4 scores. Impaired renal function and chronic kidney disease (CKD) were defined by an estimated glomerular filtration rate (eGFR) with value of < 90 mL/min/1.73 m2 and < 60 mL/min/1.73 m2, respectively, as estimated by the CKD-Epidemiology Collaboration (CKD-EPI) equation. Among 529 included NAFLD patients, the prevalence rates of impaired renal function and CKD were 37.4% and 4.9%, respectively. In multivariate analysis, a moderate-high risk of advanced liver fibrosis and cirrhosis according to Agile3+ and Agile 4 scores were independent risk factors for CKD (P < 0.05). Furthermore, increased fasting plasma glucose (FPG) and blood pressure were significantly associated with impaired renal function after controlling for the other components of metabolic syndrome (P < 0.05). Compared with patients with normoglycemia, those with prediabetes [FPG ≥ 5.6 mmol/L or hemoglobin A1c (HbA1c) ≥ 5.7%] were more likely to have impaired renal function (P < 0.05). Agile 3+ and Agile 4 are reliable for identifying NAFLD patients with high risk of CKD. Early glycemic control in the prediabetic stage might have a potential renoprotective role in these patients.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
进退须臾完成签到,获得积分10
1秒前
图图发布了新的文献求助10
1秒前
liujinjin完成签到,获得积分10
2秒前
甜甜醉波完成签到,获得积分10
2秒前
小不完成签到 ,获得积分10
3秒前
小心薛了你完成签到,获得积分10
9秒前
与离完成签到 ,获得积分10
9秒前
感性的俊驰完成签到 ,获得积分10
13秒前
疯狂的凡梦完成签到 ,获得积分10
14秒前
桥豆麻袋完成签到,获得积分10
15秒前
量子星尘发布了新的文献求助10
16秒前
Hello应助幸福的杨小夕采纳,获得10
16秒前
Lighten完成签到 ,获得积分10
17秒前
lyj完成签到 ,获得积分10
18秒前
成就茗完成签到 ,获得积分10
20秒前
ZD完成签到 ,获得积分10
29秒前
31秒前
英姑应助普鲁卡因采纳,获得10
34秒前
冰糕发布了新的文献求助10
36秒前
BettyNie完成签到 ,获得积分10
38秒前
优雅的平安完成签到 ,获得积分10
38秒前
冰糕完成签到,获得积分10
43秒前
45秒前
852应助完犊子采纳,获得10
49秒前
ruochenzu发布了新的文献求助10
50秒前
不想洗碗完成签到 ,获得积分10
52秒前
const完成签到,获得积分10
56秒前
hjx完成签到 ,获得积分10
56秒前
稳重的尔安完成签到,获得积分10
58秒前
量子星尘发布了新的文献求助10
59秒前
缓慢的饼干完成签到 ,获得积分10
59秒前
saturn完成签到 ,获得积分10
59秒前
金桔希子完成签到,获得积分10
1分钟前
Breeze完成签到 ,获得积分10
1分钟前
1分钟前
昏睡的眼神完成签到 ,获得积分10
1分钟前
文心同学完成签到,获得积分0
1分钟前
demom完成签到 ,获得积分10
1分钟前
duckspy完成签到 ,获得积分10
1分钟前
完犊子发布了新的文献求助10
1分钟前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038112
求助须知:如何正确求助?哪些是违规求助? 3575788
关于积分的说明 11373801
捐赠科研通 3305604
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022