血脑屏障
鼻腔给药
介孔二氧化硅
药物输送
体内
纳米医学
纳米技术
药理学
药品
纳米颗粒
医学
材料科学
生物医学工程
化学
中枢神经系统
介孔材料
内科学
生物
生物化学
催化作用
生物技术
作者
Bárbara Sánchez-Dengra,María Alfonso,Isabel González‐Álvarez,Marival Bermejo,Marta González‐Álvarez,Ramón Martínez‐Máñez
出处
期刊:Nanomedicine
日期:2023-10-01
卷期号:18 (25): 1799-1813
被引量:1
标识
DOI:10.2217/nnm-2023-0131
摘要
Background: Glioblastoma is the most common and lethal brain cancer. New treatments are needed. However, the presence of the blood-brain barrier is limiting the development of new treatments directed toward the brain, as it restricts the access and distribution of drugs to the CNS. Materials & methods: In this work, two different nanoparticles (i.e., mesoporous silica nanoparticles and magnetic mesoporous silica nanoparticles) loaded with ponatinib were prepared. Results & conclusion: Both particles were characterized and tested in vitro and in vivo, proving that they are not toxic for blood-brain barrier cells and they increase the amount of drug reaching the brain when administered intranasally in comparison with the results obtained for the free drug.This article presents a couple of promising nanoparticles for the treatment of brain cancer. This research is interesting because the brain and spinal cord are protected by a membrane that prevents toxic substances from reaching them but also hinders the access of drugs. One type of particle has a magnet in its core, so it can be driven with another external magnet until it reaches target; the other type does not have a magnet but has a small size, which would allow it to cross the membrane mentioned above. These particles have been proven to be able to kill cancer cells and to reach the brain after been administered through the nose in a better way than the free drug.
科研通智能强力驱动
Strongly Powered by AbleSci AI