医学
甲基强的松龙
复视
随机对照试验
入射(几何)
不利影响
临床试验
内科学
外科
物理
光学
作者
Zhang-Fang Li,Yaosheng Luo,Qin Huang,Zhi Chen,Dekun Song,Dao-Yan Pan,Shengqiang Hu,Wei Jiang,Qiuyue Cai,Xiaojun Feng,Qing Zhang,Chanyan Weng,Qiufeng Zeng,Tianlun Zhao,Chen-Zhong Li,Tong Zhang,Jie Shen
标识
DOI:10.1210/clinem/dgad476
摘要
Intravenous glucocorticoid (IVGC) is an accessible and affordable treatment for Graves orbitopathy (GO); the 4.5-g protocol is well studied, but many details of treatment protocols need to be clarified.To compare the efficacy and safety of weekly and monthly protocol of IVGC in GO.A prospective, randomized, observer-masked, single-center clinical trial, followed up to week 24, at the third affiliated hospital of Southern Medical University; 58 patients with active and moderate to severe GO, aged 18-60 years old, who had not received relevant treatment were included. The intervention was weekly protocol or monthly protocol of IVGC; both received a cumulative dose of methylprednisolone 4.5 g and had a duration of 12 weeks. The overall effective rate, improvement of quality of life (QOL) and signal intensity ratio (SIR) were measured.There was no significant difference in the effective rate between the 2 groups at week 12 and week 24 (86.21% vs 72.41%, P = .195; 86.21% vs 82.61%, P = .441), there was no significant difference in the improvement of clinical activity score, exophthalmos, soft tissue involvement, diplopia, and QOL. At week 24, the mean SIR and maximum SIR of the 2 groups were lower than those before treatment, and there were no statistically significant difference between the 2 groups. There was no significant difference in the incidence of adverse events between the 2 groups (31.03% vs 27.59%, P = .773).The efficacy and safety of the 2 protocols are comparable; the monthly protocol could be used as an alternative to the weekly protocol.
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