伤口愈合
脂质体
炎症
姜黄素
药理学
巨噬细胞极化
化学
医学
免疫学
巨噬细胞
癌症研究
生物化学
体外
作者
Qinghan Tang,Mei Dong,Zeyu Xu,Nannan Xue,Ruihan Jiang,Xuchao Wei,Jingyue Gu,Yue Li,Rongshuang Xin,Jia Wang,Xueying Xiao,Xin Zhou,Shaoping Yin,Yiwei Wang,Jun Chen
标识
DOI:10.1016/j.jconrel.2023.07.049
摘要
The excessive inflammatory response is known to be a major challenge for diabetic wound healing, while bacteria secreted toxin, α-hemolysin (Hlα), was recently reported to prolong inflammation and delay diabetic wound healing. In this study, we designed a red blood cell membrane (RBCM)-mimicking liposome containing curcumin (named RC-Lip) for the treatment of diabetic wounds. RC-Lips were successfully fabricated using the thin film dispersion method, and the fusion of RBC membrane with the liposomal membrane was confirmed via surface protein analysis. RC-Lips efficiently adsorbed Hlα, thereby reducing the damage and pro-apoptotic effects of Hlα on keratinocytes. Furthermore, they remarkably facilitated liposome uptake into macrophages with advanced curcumin release and regulation of M2 macrophage polarization. In a diabetic mouse and infected wound model, RC-Lips treatment significantly promoted wound healing and re-epithelialization while downregulating interleukin-1β (IL-1β) and upregulating interleukin-10 (IL-10). In summary, the results showed that the spongiform RC-Lips effectively modulate the inflammatory response after adsorbing Hlα and regulating M2 macrophage polarization, leading to a significant promotion of wound healing in diabetic mice. Hence, this study provides a prospective strategy of efficiently mediating inflammatory response for diabetic wounds.
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