肌酐
肾
肾脏疾病
氧化应激
内分泌学
肾功能
内科学
医学
蛋白尿
化学
药理学
作者
Mahmoud M. Samaha,Omnia A. Nour,Haitham M. Sewilam,Dalia H. El‐Kashef
出处
期刊:Life Sciences
[Elsevier]
日期:2023-09-09
卷期号:331: 122080-122080
被引量:3
标识
DOI:10.1016/j.lfs.2023.122080
摘要
Chronic kidney disease (CKD) is a serious problem which negatively affects human health.The purpose of this investigation was to explore the possible beneficial impacts of diacerein on adenine-induced CKD in rats.32 male Sprague Dawley rats were allocated into 4 groups; normal, diseased (200 mg/kg adenine, orally) and diacerein (25 and 50 mg/kg, orally).Adenine produced marked reduction in rats' body weights and a substantial increase in kidney/body weight index. Additionally, adenine significantly increased serum creatinine and BUN levels besides proteinuria levels, and also reduced creatinine clearance. Adenine induced oxidative stress as evidenced by increased MDA content and diminished GSH concentration in renal tissues. These biochemical measurements were confirmed by the morphological and histopathological results. Moreover, adenine revealed substantial elevation in renal level and expression of MYD88, TRAF6 and TNF-α, and renal level of IL-1β in addition to increased expression of TLR4, NF-κB p65 and p-NF-κB p65 while reduced the expression of IκB-α. Diacerein in a dose-dependent manner effectively ameliorated adenine-induced alterations.Diacerein could be used as a therapeutic agent to attenuate CKD after further clinical studies.
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