全国健康与营养检查调查
维生素D与神经学
后备箱
维生素
肥胖
内科学
医学
体质指数
内分泌学
沉积(地质)
动物科学
化学
生物
人口
环境卫生
生态学
古生物学
沉积物
作者
Qian Ren,Danfeng Xu,Jing Liang,Yun Cao,Lili Zhang,Shengfang Ge,Peizhan Chen
标识
DOI:10.1016/j.nutres.2023.11.001
摘要
The aim of the study was to explore the relationship between serum 25-hydroxyvitamin D [25(OH)D] concentrations and regional body fat deposition in 2011–2018 National Health and Nutrition Examination Survey participants aged 18–59 years old. We hypothesized that serum 25(OH)D concentrations were negatively associated with total, appendicular, and truncal fat deposition. Serum 25(OH)D concentration was categorized into sufficient (≥75.0 nM), insufficient (50.0 to 74.9 nM), and deficient (<50.0 nM) groups. Fat mass (FM) was measured by dual-energy X-ray absorptiometry, and FM index (FMI) was calculated by dividing FM (kg) with height2 (m2). Multivariant linear regression and Granger causal analysis were performed to assess the causal relationship between vitamin D status and regional FMIs. Overall serum 25(OH)D concentrations were negatively associated with total (β = -0.029, SE = 0.002), trunk (β = -0.015, SE = 0.001), arms (β = -0.004, SE = 3.09×10−4), and legs (β = -0.010, SE = 0.001) FMIs in all participants (P <0.001, respectively); however, after stratified by vitamin D status and BMI, the negative associations were only observed in individuals with vitamin D deficiency and obesity. The causal analysis indicated that serum 25(OH)D concentrations may causally reduce the arms (F = 4.917, Prob. = 0.007), legs (F = 5.783, Prob. = 0.003), and total (F = 3.202, Prob. = 0.041) FMIs except for trunk FMI but not vice versa. In conclusion, poor vitamin D status was associated with increased total and appendicular body fat deposition in US adults, particularly in participants with obesity.
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