The construction of hierarchical assemblies with in situ generation of chemotherapy drugs to enhance the efficacy of chemodynamic therapy for multi-modal anti-tumor treatments

The use of the chemotherapeutic prodrug disulfiram (DSF) increased the Cu + /Cu 2+ ratio, leading to enhanced efficacy of chemo-dynamic therapy (CDT) and in situ generation of the chemotherapy drug CuET. This approach enables a highly efficient combined anti-tumor treatment.