Effects of Blood Hemoadsorption Therapy with HA-380 in Total Arch Replacement for Acute Type A Aortic Dissection: A Retrospective Observational Study

医学 肾脏替代疗法 围手术期 主动脉夹层 急性肾损伤 回顾性队列研究 外科 体外循环 胃肠病学 麻醉 内科学 主动脉
作者
Juxiang Wang,Bin Chen,Junhao Xie,Huilong Chen,Lihua Li,Weiqun Zhang,Lin Lü
出处
期刊:Blood Purification [S. Karger AG]
卷期号:53 (2): 138-150
标识
DOI:10.1159/000534852
摘要

<b><i>Introduction:</i></b> This study aimed to evaluate whether the addition of a hemoadsorption (HA) cartridge, HA-380, in the cardiopulmonary bypass (CPB) circuit in acute type A aortic dissection (ATAAD) surgery reduced inflammatory cytokine levels and decreased postoperative complications. <b><i>Methods:</i></b> A retrospective observational cohort study was conducted between March 1, 2021, and February 28, 2022. Patients with ATAAD undergoing emergent total arch replacement surgery were divided into the control (CON) and HA groups on the basis of the addition of the HA-380 cartridge in the CPB circuit. <b><i>Results:</i></b> Overall, 121 patients met the eligibility criteria; 2 patients in each group who died within the first postoperative week were excluded. Further, 57 and 60 patients in the CON and HA groups, respectively, were included in the pooled analysis. The major perioperative data, baseline values of interleukin-6 (IL-6) and C-reactive protein, and therapeutic interventions were similar in the two groups (all, <i>p &gt; 0.05</i>). The serum IL-6 levels increased more rapidly in the CON group than those in the HA group postoperatively (205.73 ± 174.72 vs. 146.13 ± 64.15 pg/mL, <i>p</i> = 0.020). The HA group had a lower incidence of postoperative acute kidney injury (AKI) and severe acute respiratory distress syndrome than the CON group (25.4 vs. 44.6%, <i>p</i> = 0.032 and 18.3 vs. 35.1%, <i>p</i> = 0.040, respectively). Logistic regression analyses showed that HA may be a protective factor against postoperative AKI. The incidence of bleeding, delirium, and stroke as well as the lengths of intensive care unit and hospital stay in both groups were similar (all, <i>p &gt;</i> 0.05). <b><i>Conclusions:</i></b> The use of HA-380 in the CPB circuit may attenuate inflammatory response and reduce major complications following ATAAD surgery. HA may be associated with lower rate of postoperative AKI.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
echo完成签到 ,获得积分10
1秒前
1秒前
美好焦完成签到,获得积分10
1秒前
麦子完成签到 ,获得积分10
1秒前
LC完成签到 ,获得积分10
2秒前
2秒前
难过的初柔应助paopao采纳,获得10
3秒前
zxcvb发布了新的文献求助30
3秒前
星辰大海应助tesla采纳,获得10
4秒前
madison发布了新的文献求助10
4秒前
zoey完成签到,获得积分10
4秒前
黄嘟嘟完成签到,获得积分10
4秒前
NICKPLZ完成签到,获得积分10
4秒前
小鬼完成签到,获得积分10
5秒前
WANGGE完成签到 ,获得积分10
5秒前
小巧凝丹完成签到,获得积分10
7秒前
7秒前
funny发布了新的文献求助10
8秒前
8秒前
大模型应助芝士就是力量采纳,获得10
9秒前
田様应助小闲鱼采纳,获得10
9秒前
活泼凌青完成签到,获得积分10
9秒前
小糊涂仙完成签到,获得积分10
9秒前
科研通AI5应助王悦采纳,获得10
10秒前
杨青月完成签到,获得积分10
10秒前
上官若男应助yuncong323采纳,获得10
10秒前
dandan完成签到,获得积分10
11秒前
风趣的天问完成签到 ,获得积分10
11秒前
yi完成签到,获得积分10
11秒前
姚怜南发布了新的文献求助10
11秒前
王二哈完成签到,获得积分10
12秒前
糊涂的马里奥完成签到 ,获得积分10
12秒前
12秒前
liutg24完成签到,获得积分10
13秒前
Honey完成签到,获得积分10
13秒前
waoller1完成签到,获得积分10
13秒前
灵巧高山应助paopao采纳,获得10
13秒前
zhouxiuman完成签到,获得积分10
13秒前
JJ完成签到,获得积分10
13秒前
打打应助浮生采纳,获得10
13秒前
高分求助中
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Mechanistic Modeling of Gas-Liquid Two-Phase Flow in Pipes 2500
Structural Load Modelling and Combination for Performance and Safety Evaluation 800
Conference Record, IAS Annual Meeting 1977 610
Virulence Mechanisms of Plant-Pathogenic Bacteria 500
白土三平研究 500
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3556011
求助须知:如何正确求助?哪些是违规求助? 3131566
关于积分的说明 9392042
捐赠科研通 2831431
什么是DOI,文献DOI怎么找? 1556440
邀请新用户注册赠送积分活动 726584
科研通“疑难数据库(出版商)”最低求助积分说明 715910