Dietary chenodeoxycholic acid attenuates high-fat diet-induced growth retardation, lipid accumulation and bile acid metabolism disorder in the liver of yellow catfish Pelteobagrus fulvidraco

鹅去氧胆酸 内科学 脂质代谢 胆汁酸 法尼甾体X受体 内分泌学 胆酸 鲶鱼 脂肪生成 化学 胆固醇 生物 生物化学 医学 核受体 渔业 基因 转录因子
作者
Hua Zheng,Yi-Chuang Xu,Tao Zhao,Zhi Luo,Dian-Guang Zhang,Chang-Chun Song,An-Gen Yu,Xiao-Ying Tan
出处
期刊:British Journal of Nutrition [Cambridge University Press]
卷期号:131 (6): 921-934 被引量:6
标识
DOI:10.1017/s0007114523002489
摘要

Abstract This experiment was conducted to investigate whether dietary chenodeoxycholic acid (CDCA) could attenuate high-fat (HF) diet-induced growth retardation, lipid accumulation and bile acid (BA) metabolism disorder in the liver of yellow catfish Pelteobagrus fulvidraco . Yellow catfish (initial weight: 4·40 ( sem 0·08) g) were fed four diets: the control (105·8 g/kg lipid), HF diet (HF group, 159·6 g/kg lipid), the control supplemented with 0·9 g/kg CDCA (CDCA group) and HF diet supplemented with 0·9 g/kg CDCA (HF + CDCA group). CDCA supplemented in the HF diet significantly improved growth performance and feed utilisation of yellow catfish ( P < 0·05). CDCA alleviated HF-induced increment of hepatic lipid and cholesterol contents by down-regulating the expressions of lipogenesis-related genes and proteins and up-regulating the expressions of lipololysis-related genes and proteins. Compared with the control group, CDCA group significantly reduced cholesterol level ( P < 0·05). CDCA significantly inhibited BA biosynthesis and changed BA profile by activating farnesoid X receptor ( P < 0·05). The contents of CDCA, taurochenodeoxycholic acid and glycochenodeoxycholic acid were significantly increased with the supplementation of CDCA ( P < 0·05). HF-induced elevation of cholic acid content was significantly attenuated by the supplementation of CDCA ( P < 0·05). Supplementation of CDCA in the control and HF groups could improve the liver antioxidant capacity. This study proved that CDCA could improve growth retardation, lipid accumulation and BA metabolism disorder induced by HF diet, which provided new insight into understanding the physiological functions of BA in fish.
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