组蛋白八聚体
生物
组蛋白
核小体
染色质
组蛋白甲基转移酶
细胞生物学
组蛋白H1
染色质重塑
组蛋白修饰酶
组蛋白H2A
组蛋白密码
组蛋白甲基化
遗传学
DNA
DNA甲基化
基因表达
基因
作者
Ann Hogan,Daniel R. Foltz
摘要
The eukaryotic genome is packaged into chromatin. The nucleosome, the basic unit of chromatin, is composed of DNA coiled around a histone octamer. Histones are among the longest-lived protein species in mammalian cells due to their thermodynamic stability and their associations with DNA and histone chaperones. Histone metabolism plays an integral role in homeostasis. While histones are largely stable, the degradation of histone proteins is necessary under specific conditions. Here, we review the physiological and cellular contexts that promote histone degradation. We describe specific known mechanisms that drive histone proteolysis. Finally, we discuss the importance of histone degradation and regulation of histone supply for organismal and cellular fitness.
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