介孔材料
超顺磁性
材料科学
纳米技术
药物输送
奥斯特瓦尔德成熟
化学工程
介孔二氧化硅
分散性
聚乙烯吡咯烷酮
化学
有机化学
高分子化学
磁化
催化作用
工程类
物理
磁场
量子力学
作者
Fang Wang,Xiongwei Qi,Jiahong Geng,Xiaoyan Liu,Dong Li,Hui Zhang,Peng Zhang,Xiaolei He,Baowei Li,Zhijia Li,Ruitao Yu,Xiaoying Yang,Guangshuo Wang
标识
DOI:10.1016/j.molliq.2021.118000
摘要
Monodisperse hollow mesoporous Fe3O4 nanospheres have been successfully synthesized via a template-free one-pot solvothermal method under the existence of iron chloride hexahydrate, polyvinylpyrrolidone and urea. A proposed gas-bubble-assisted Ostwald ripening mechanism was allowed to explain the possible fabrication of hollow nanostructures. The formed Fe3O4 nanospheres possessed a narrow particle size distribution with a average hydrodynamic diameter of 392 nm, superparamagnetic characteristics with high saturation magnetization of 74.9 emu/g, as well as the typical mesoporous structures with specific surface area of 27.3 m2/g. Furthermore, it was found that the bare hollow mesoporous Fe3O4 nanospheres showed an insignificant cytotoxicity, but exhibited obvious cytotoxic effects towards HeLa cells after being loaded with the anti-cancer drug of DOX, which could be recommended as a promising and effective drug delivery system with high drug loading capacity and pH-responsive feature. The determined maximum drug loading capacity of DOX on this kind of hollow mesoporous Fe3O4 nanospheres was as high as 0.36 ± 0.04 g/g, which can store and deliver effectively the anticancer drugs to induce death of cancer cells.
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