心磷脂
生物
线粒体融合
磷脂酸
细胞生物学
细胞器
脂质双层融合
动力素
线粒体内膜
线粒体
GTP酶
内膜转移酶
生物化学
线粒体载体
线粒体分裂
心磷脂
膜脂
线粒体膜转运蛋白
膜
细菌外膜
磷脂
线粒体DNA
细胞
基因
大肠杆菌
内吞作用
作者
Shoichiro Kameoka,Yoshihiro Adachi,Koji Okamoto,Miho Iijima,Hiromi Sesaki
标识
DOI:10.1016/j.tcb.2017.08.011
摘要
Membrane organelles comprise both proteins and lipids. Remodeling of these membrane structures is controlled by interactions between specific proteins and lipids. Mitochondrial structure and function depend on regulated fusion and the division of both the outer and inner membranes. Here we discuss recent advances in the regulation of mitochondrial dynamics by two critical phospholipids, phosphatidic acid (PA) and cardiolipin (CL). These two lipids interact with the core components of mitochondrial fusion and division (Opa1, mitofusin, and Drp1) to activate and inhibit these dynamin-related GTPases. Moreover, lipid-modifying enzymes such as phospholipases and lipid phosphatases may organize local lipid composition to spatially and temporarily coordinate a balance between fusion and division to establish mitochondrial morphology.
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