解旋酶
eIF4A标准
核糖核酸
生物
RNA解旋酶A
端粒
细胞生物学
抄写(语言学)
RNA沉默
信使核糖核酸
长寿
遗传学
翻译(生物学)
非编码RNA
RNA干扰
基因
哲学
语言学
作者
Sang‐Soon Park,Hae‐Eun H. Park,Heehwa G. Son,Seung‐Jae Lee
标识
DOI:10.1016/j.tma.2017.08.001
摘要
RNA helicases are members of a large family of enzymes that function in unwinding RNA duplexes and modulating interactions between RNAs and proteins. RNA helicases participate in numerous cellular processes, including transcription, translation, mRNA export, nonsense-mediated mRNA decay, and telomere maintenance. In this review, we discuss the recent discoveries on several RNA helicases that play key roles in aging and lifespan regulation. We first describe the roles of several mammalian RNA helicases implicated in cellular senescence. In addition, we discuss our previous reports showing that three RNA helicases, HEL-1/DDX39, SACY-1/DDX41 and SMG-2/UPF1, promote longevity in Caenorhabditis elegans through distinct mechanisms. These findings reveal the critical functions of many RNA helicases in regulating aging and may lead to insights into the importance of RNA homeostasis in aging and longevity.
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