现状
临床前研究
临床前试验
相关性(法律)
观察研究
转化研究
生物
计算生物学
医学
医学物理学
病理
政治学
法学
作者
Nicolas Gengenbacher,Mahak Singhal,Hellmut G. Augustin
出处
期刊:Nature Reviews Cancer
[Springer Nature]
日期:2017-10-27
卷期号:17 (12): 751-765
被引量:252
摘要
Oncology research in humans is limited to analytical and observational studies for obvious ethical reasons, with therapy-focused clinical trials being the one exception to this rule. Preclinical mouse tumour models therefore serve as an indispensable intermediate experimental model system bridging more reductionist in vitro research with human studies. Based on a systematic survey of preclinical mouse tumour studies published in eight scientific journals in 2016, this Analysis provides an overview of how contemporary preclinical mouse tumour biology research is pursued. It thereby identifies some of the most important challenges in this field and discusses potential ways in which preclinical mouse tumour models could be improved for better relevance, reproducibility and translatability.
科研通智能强力驱动
Strongly Powered by AbleSci AI