基因亚型
血小板
转化生长因子
细胞因子
转化生长因子β
细胞生物学
化学
免疫学
生物
转化生长因子β信号通路
分子生物学
生物化学
基因
作者
David W. Grainger,David E. Mosedale,James C. Metcalfe
标识
DOI:10.1016/s1359-6101(99)00037-4
摘要
The cytokine transforming growth factor-beta (TGF-beta) was initially purified from human platelets, a rich source of this protein. In addition to platelets, TGF-beta1 is also found in other blood fractions, including plasma and the circulating leukocytes. However, more than 15 years after the initial isolation of TGF-beta1, there remains no consensus on how much TGF-beta1 is present in normal human plasma. Here we review the difficulties associated with measuring TGF-beta concentrations in complex biological fluids, and discuss the current state of knowledge on the distribution of TGF-beta isoforms in various blood fractions as well as the nature of the TGF-beta-containing protein complexes.
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