光热治疗
纳米棒
体内
热疗
胶体金
光热效应
基底细胞
癌症研究
医学
纳米颗粒
等离子纳米粒子
癌细胞
癌症
病理
光电子学
光动力疗法
细胞凋亡
化学
材料科学
内科学
纳米技术
生物
生物技术
作者
Erin B. Dickerson,Erik C. Dreaden,Xiaolin Huang,Ivan H. El-Sayed,Hunghao Chu,Sujatha Pushpanketh,John F. McDonald,Mostafa A. El-Sayed
出处
期刊:Cancer Letters
[Elsevier]
日期:2008-09-28
卷期号:269 (1): 57-66
被引量:990
标识
DOI:10.1016/j.canlet.2008.04.026
摘要
Plasmonic photothermal therapy (PPTT) is a minimally-invasive oncological treatment strategy in which photon energy is selectively administered and converted into heat sufficient to induce cellular hyperthermia. The present work demonstrates the feasibility of in vivo PPTT treatment of deep-tissue malignancies using easily-prepared plasmonic gold nanorods and a small, portable, inexpensive near-infrared (NIR) laser. Dramatic size decreases in squamous cell carcinoma xenografts were observed for direct (P<0.0001) and intravenous (P<0.0008) administration of pegylated gold nanorods in nu/nu mice. Inhibition of average tumor growth for both delivery methods was observed over a 13-day period, with resorption of >57% of the directly-injected tumors and 25% of the intravenously-treated tumors.
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