Spinal interleukin-1 β reduces inflammatory pain

伤害 痛觉过敏 医学 炎症 细胞因子 有害刺激 脊髓 中枢神经系统 伤害感受器 外围设备 免疫学 麻醉 药理学 内科学 受体 精神科
作者
Andrew J. Souter,Mary G. Garry
出处
期刊:Pain [Ovid Technologies (Wolters Kluwer)]
卷期号:86 (1): 63-68 被引量:36
标识
DOI:10.1016/s0304-3959(99)00315-2
摘要

Inflammation or injury often lead to chronic pain states such as hyperalgesia where the perception of a normally painful stimulus is significantly exaggerated. Interleukin-1β (IL-1β) is a cytokine that is an important mediator of the inflammatory response. In addition, IL-1β has been implicated in the modulation of pain transmission in both the peripheral and central nervous systems. We evaluated the spinal effect of this cytokine in the presence and absence of a peripheral carrageenan inflammation in rats since the spinal cord is a major region of the central nervous system in which nociceptive input is processed and modulated. Our results indicate that intrathecal IL-1β has no effect on the latency of paw withdrawal in response to a noxious thermal stimuluation in normal rats. In contrast, we have observed that IL-1β produces significant antinociception when administered intrathecally in rats with peripheral inflammation (carrageenan model). The IL-1β effect appears to be selective as it is reversed when IL-1β is administered in the presence of an IL-1β neutralizing antibody. We evaluated some putative mechanisms of this IL-1β-mediated antinociception and found it to be non-opioid-dependent. Collectively, these data indicate that intrathecal IL-1β has no effect on the processing of thermal nociceptive information in the absence of a peripheral inflammation. Therefore, the response to acute pain remains normal in these rats. In contrast, IL-1β is antinociceptive when applied spinally during inflammation. These results indicate that IL-1β reduces inflammatory hyperalgesia while sparing the protective functions of acute pain. This study offers new insights into the role of IL-1β and nociceptive processing at the level of the spinal cord and suggests that development of IL-1β agonists may be an alternative to opiate based therapies in the treatment of inflammatory pain.
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