血管生成
α-vβ-3
整合素
新生血管
绒毛尿囊膜
阿尔法(金融)
肉芽组织
血管
BETA(编程语言)
碱性成纤维细胞生长因子
伤口愈合
生物
癌症研究
分子生物学
细胞生物学
维生素连接蛋白
免疫学
生长因子
受体
医学
内分泌学
生物化学
患者满意度
程序设计语言
计算机科学
护理部
结构效度
作者
Peter C. Brooks,Richard A.F. Clark,David A. Cheresh
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1994-04-22
卷期号:264 (5158): 569-571
被引量:3013
标识
DOI:10.1126/science.7512751
摘要
Angiogenesis depends on the adhesive interactions of vascular cells. The adhesion receptor integrin α v β 3 was identified as a marker of angiogenic vascular tissue. Integrin α v β 3 was expressed on blood vessels in human wound granulation tissue but not in normal skin, and it showed a fourfold increase in expression during angiogenesis on the chick chorioallantoic membrane. In the latter assay, a monoclonal antibody to α v β 3 blocked angiogenesis induced by basic fibroblast growth factor, tumor necrosis factor-α, and human melanoma fragments but had no effect on preexisting vessels. These findings suggest that α v β 3 may be a useful therapeutic target for diseases characterized by neovascularization.
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