真细菌
瘤胃球菌
氧化三甲胺
拟杆菌
嗜血杆菌
普氏粪杆菌
肠道菌群
乳酸菌
微生物学
内科学
三甲胺
链球菌
A组
生物
胃肠病学
医学
食品科学
细菌
免疫学
生物化学
发酵
遗传学
作者
I.O. Melnychuk,V. G. Lizogub
出处
期刊:Wiadomości lekarskie (Warsaw Poland)
[Foundation of Polish Physicians-Pro-Medica]
日期:2022-01-01
卷期号:75 (12): 2994-2999
被引量:3
标识
DOI:10.36740/wlek202212117
摘要
The aim: To check changes of gut microbiota composition and its metabolites in atherosclerosis (AS) patients with or without atrial fibrillation (AF) and special connections between them and important clinic and laboratory features of investigated groups. Materials and methods: 300 patients were investigated. All investigated were divided into 3 groups: control group (CG) – 27 patients without AS and arrhythmias; mean group – 149 patients with AS but without arrhythmias; comparable group – 124 patients with AS and AF paroxysm. By 16-S rRNA sequencing was checked gut microbiota composition. The level of trimethylamine-N-oxide (TMAO), trimethylamine (TMA) plasma was determined by gas chromatography with mass electron detection. Results: The mean and comparable groups have the significant abundance of total bacterial mass, Bacteroides Spp., Faecalibacterium Prausnitzii, Actinobacter Spp. and decreas¬ing Ruminococcus Spp. In the comparable group to the mean significant increasing of Actinobacter Spp. and decreasing Eubacterium Rectale, Ruminococcus Spp. were checked. Bacteroides Fragilis Group/ Faecalibacterium Prausnitzii ratio was significantly higher than in patients’ comparable group. In the mean group patients compared with CG significant abundance of Streptococcus Spp. was checked. In the comparable group compared with CG significant leak of Eubacterium Rectale was checked. The highest amount of correlations was between Lactobacillus Spp., Streptococcus Spp. and clinic-laboratory changes. The mean and comparable groups the significant increasing of TMA ta TMAO plasma levels were checked. In patients of comparable group compared with patients mean group the significant increasing of TMAO plasma level was revealed. Conclusions: We checked special bacterial changes of gut microbiota that are common for patients with AS and AF comparable with AS patients. TMAO plasma levels are increased significantly for patients with AS and AF comparable with AS patients. Connections between AS and AF with TMAO plasma levels are confirmed by reliable correlations between TMAO and age, BMI, GFR, HDL levels. Special bacterial species are closely connected with age, BMI, GFR, HDL, LDL, plasma TMA and TMAO levels.
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