Cardiovascular variations in patients with major depressive disorder versus bipolar disorder

双相情感障碍 心脏病学 重性抑郁障碍 医学 双相情感障碍 心情 心理学 临床心理学 精神科 锂(药物)
作者
Fei Xie,Linlin Zhou,Qiang Hu,Lingyun Zeng,YanYan Wei,XiaoChen Tang,YuQing Gao,YeGang Hu,Lihua Xu,Tao Chen,HaiChun Liu,Jijun Wang,Zheng Lu,YingYao Chen,Tianhong Zhang
出处
期刊:Journal of Affective Disorders [Elsevier BV]
卷期号:341: 219-227 被引量:3
标识
DOI:10.1016/j.jad.2023.08.128
摘要

Differentiating depression in major depressive disorder and bipolar disorder is challenging in clinical practice. Therefore, reliable biomarkers are urgently needed to differentiate between these diseases. This study's main objective was to assess whether cardiac autonomic function can distinguish patients with unipolar depression (UD), bipolar depression (BD), and bipolar mania (BM). We recruited 791 patients with mood disorders, including 191 with UD, 286 with BD, and 314 with BM, who had been drug free for at least 2 weeks. Cardiovascular status was measured using heart rate variability (HRV) and pulse wave velocity (PWV) indicators via finger photoplethysmography during a 5-min rest period. Patients with BD showed lower HRV but higher heart rates than those with UD and BM. The PWV indicators were lower in the UD group than in the bipolar disorder group. The covariates of age, sex, and body mass index affected the cardiovascular characteristics. After adjusting for covariates, the HRV and PWV variations among the three groups remained significant. Comparisons between the UD and BD groups showed that the variable with the largest effect size was the frequency-domain indices of HRV, very low and high frequency, followed by heart rate. The area under the receiver operating characteristic curve (AUC) for each cardiovascular variable ranged from 0.661 to 0.714. The High-frequency index reached the highest AUC. Limitations. Cross-sectional design and the magnitude of heterogeneity across participants with mood disorders limited our findings. Patients with BD, but not BM, had a greater extent of cardiac imbalance than those with UD. Thus, HRV may serve as a psychophysiological biomarker for the differential diagnosis of UD and BD.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
潘善若发布了新的文献求助10
1秒前
Fengliguantou发布了新的文献求助10
2秒前
量子星尘发布了新的文献求助10
3秒前
李健的小迷弟应助momo采纳,获得10
4秒前
6秒前
大模型应助xueyu采纳,获得10
9秒前
做一只快乐的猪猪侠完成签到,获得积分20
9秒前
9秒前
酷炫的之柔完成签到,获得积分10
10秒前
xunxunmimi发布了新的文献求助10
12秒前
13秒前
乂贰ZERO叁完成签到 ,获得积分10
13秒前
思源应助酷炫的之柔采纳,获得10
14秒前
xiaohu发布了新的文献求助10
14秒前
Ant应助小李采纳,获得30
15秒前
16秒前
16秒前
苹果初阳发布了新的文献求助10
19秒前
此间少年完成签到,获得积分10
19秒前
21秒前
Hairee发布了新的文献求助10
21秒前
思源应助baonali采纳,获得10
22秒前
WXR完成签到,获得积分10
24秒前
蓝胖胖蓝完成签到,获得积分10
25秒前
蜘蛛道理完成签到 ,获得积分10
25秒前
LZM完成签到,获得积分10
26秒前
WuLunbi发布了新的文献求助10
27秒前
28秒前
29秒前
29秒前
30秒前
我还以为春天到了完成签到 ,获得积分10
30秒前
亲爱的融完成签到,获得积分10
31秒前
SherlockHe发布了新的文献求助10
32秒前
momo发布了新的文献求助10
33秒前
米饭多加水完成签到 ,获得积分10
35秒前
潘善若发布了新的文献求助10
36秒前
Jasper应助anna采纳,获得10
40秒前
zzr元亨利贞完成签到,获得积分10
42秒前
riccixuu完成签到 ,获得积分10
43秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989263
求助须知:如何正确求助?哪些是违规求助? 3531418
关于积分的说明 11253814
捐赠科研通 3270066
什么是DOI,文献DOI怎么找? 1804884
邀请新用户注册赠送积分活动 882084
科研通“疑难数据库(出版商)”最低求助积分说明 809136