败血症
医学
免疫抑制
发病机制
免疫学
免疫系统
细胞凋亡
肝损伤
巨噬细胞
癌症研究
内科学
生物
遗传学
体外
作者
Shanshou Liu,Jiangang Xie,Chujun Duan,Xiaojun Zhao,Zhusheng Feng,Zheng Dai,Luo Xu,Yu Li,Monica Yang,Ran Zhuang,Junjie Li,Kuo Shen
出处
期刊:Journal of clinical and translational hepatology
[Xia & He Publishing]
日期:2023-11-13
卷期号:000 (000): 000-000
标识
DOI:10.14218/jcth.2023.00171
摘要
Background and AimsAs sepsis progresses, immune cell apoptosis plays regulatory roles in the pathogenesis of immunosuppression and organ failure. We previously reported that adenosine deaminases acting on RNA-1 (ADAR1) reduced intestinal and splenic inflammatory damage during sepsis. However, the roles and mechanism of ADAR1 in sepsis-induced liver injury remain unclear.
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