阿尔茨海默病
神经科学
淀粉样蛋白(真菌学)
炎症
β淀粉样蛋白
疾病
神经退行性变
发病机制
谷氨酸受体
神经递质
受体
药理学
肽
化学
医学
生物
中枢神经系统
生物化学
免疫学
内科学
病理
作者
Jagdish C. Gupta,Kuldeep Singh
出处
期刊:Current Molecular Medicine
[Bentham Science]
日期:2023-09-07
卷期号:23
标识
DOI:10.2174/1566524023666230907115753
摘要
Abstract: Bioactive peptides are a promising class of therapeutics for the treatment of diseases associated with Alzheimer's and brain disorders. These peptides are derived from naturally occurring proteins and have been shown to possess a variety of beneficial properties. They may modulate neurotransmitter systems, reduce inflammation, and improve cognitive performance. In addition, bioactive peptides have the potential to target specific molecular pathways involved in the pathogenesis of Alzheimer's and brain disorders. For example, peptides have been shown to interact with amyloid-beta, a major component of amyloid plaques found in Alzheimer's disease, and have been shown to reduce its accumulation in the brain. Furthermore, peptides have been found to modulate the activity of glutamate receptors, which are important for memory and learning, as well as to inhibit the activity of enzymes involved in the formation of toxic amyloid-beta aggregates. Finally, bioactive peptides have the potential to reduce oxidative stress and inflammation, two major components of many neurological disorders. These peptides could be used alone or in combination with traditional pharmacological treatments to improve the management of diseases associated with Alzheimer's and brain disorders.
科研通智能强力驱动
Strongly Powered by AbleSci AI