纳米纤维
细胞生物学
自愈水凝胶
免疫系统
间充质干细胞
再生(生物学)
化学
巨噬细胞
巨噬细胞极化
材料科学
纳米技术
生物化学
免疫学
生物
体外
有机化学
作者
Fan Zhang,Mingchen Lv,Siyuan Wang,Mengyao Li,Yu Wang,Congjiao Hu,Wei Hu,Xuekui Wang,Wei Wang,Zhiduo Liu,Zhen Fan,Jianzhong Du,Yao Sun
标识
DOI:10.1016/j.bioactmat.2023.08.008
摘要
The immune microenvironment plays a vital role in bone defect repair. To create an immune microenvironment that promotes osteogenesis, researchers are exploring ways to enhance the differentiation of M2-type macrophages. Functional peptides have been discovered to effectively improve this process, but they are limited by low efficiency and rapid degradation in vivo. To overcome these issues, peptide with both M2 regulatory and self-assembly modules was designed as a building block to construct an ultrasound-responsive nanofiber hydrogel. These nanofibers can be released from hydrogel in a time-dependent manner upon ultrasound stimulation, activating mitochondrial glycolytic metabolism and the tricarboxylic acid cycle, inhibiting reactive oxygen species production and enhancing M2 macrophage polarization. The hydrogel exhibits advanced therapeutic potential for bone regeneration by triggering M2 macrophages to secrete BMP-2 and IGF-I, accelerating the differentiation of bone marrow mesenchymal stem cells (BMSCs) into osteoblasts. Thus, modularly designed biomimetic ultrashort peptide nanofiber hydrogels provide a novel strategy to rebuild osteogenic immune microenvironments for bone repair.
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